• Aatube@kbin.melroy.org
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    6 months ago

    WHO report

    someone else online summarized the genetics part as the following:

    Mandelian randomisation studies show that LDL-c is causative in atherogenic plaques 1 and metabolic ward RCTs show that SFA intakes increase LDL-c, while the decrease in SFAs lead to lower total and LDL-c 2.

    But yes, almost all nutrition science is a bit inconclusive because of genetic variation.

    • fine_sandy_bottom@discuss.tchncs.de
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      6 months ago

      Forgive me, because I’m struggling to understand the linked information, but as someone with atherosclerosis this is an issue close to my heart (ha!).

      I just want to make sure I understand you.

      Your link to the european heart journal says that the causal link between LDL and ASCVD is “unequivocal”.

      I think the WHO study says (amongst a lot of other complicated stuff) that replacing SFAs with PUFAs and MUFAs is more favourable than replacing SFAs with complex carbohydrates? The strong implication being (although I couldn’t see this exactly) that higher SFA intake contributes to heart disease.

      • Aatube@kbin.melroy.org
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        6 months ago

        I don’t think it tries to compare carbohydrates to any UFAs, but the implication is indeed that SFAs significantly contribute to heart disease.