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XKCD
Calvin & Hobbes I guess doesn’t count.
I don’t have a single favorite one, so here is a top three, in no particular order:
Freefall The first webcomic i read, started in 1998 and still updating three times a week.
El Goonish Shive Another longrunner, started 2002 and still going. Helped me with figuring out some gender stuff.
How to be a werewolf Newest one on the list, starting in 2015, also still going.
That looks great!
The collaborative open source approach is very interesting too
Oglaf (NSFW)
Some good weird shit there. I sent this one to my partner: https://www.oglaf.com/skin-tight/ (NSFW)
What the fuck